Human MAGED2 ELISA Kit (HUFI03531)

The MAGED2 (Melanoma-Associated Antigen D2) protein ELISA from Assay Genie provides researchers with a quantitative tool to measure this MAGE-family member in human blood-derived samples. MAGED2 has attracted significant research interest following the identification of loss-of-function mutations as a cause of transient antenatal Bartter syndrome type V, a severe renal salt-wasting disorder characterized by polyhydramnios, prematurity, and postnatal polyuria. Studies in human genetics and nephrology continue to use MAGED2 measurements to investigate prenatal renal tubule maturation and sodium transporter regulation, including NKCC2 and NCC expression in the thick ascending limb of Henle.

Beyond renal research, MAGED2 is expressed broadly in the developing central nervous system and has been examined in studies of neural differentiation and synaptic signaling. The protein has also been explored as a marker in tumor biology research, where reactivation of MAGE-family antigens has been linked to cancer-testis antigen expression profiles.

This Assay Genie kit is supplied as 96 assays on a single-use microplate and uses a colorimetric method compatible with standard laboratory plate readers. Each kit includes the necessary reagents to measure circulating MAGED2 levels in human samples, supporting studies in nephrology, prenatal medicine, oncology biomarker discovery, and neuroscience research.