Human Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit

Encoded by the LNPEP gene on chromosome 5q15, Leucyl/Cystinyl Aminopeptidase is a zinc-dependent type II transmembrane metallopeptidase that functions as the principal receptor for angiotensin IV and participates in the metabolism of vasoactive peptides. The Assay Genie ELISA Kit enables quantitative measurement of LNPEP in human samples including serum or plasma, and in tissue homogenates.

Researchers studying hypertensive and cardiovascular disorders rely on this assay to investigate the enzymatic regulation of the renin-angiotensin system, since LNPEP cleaves angiotensin II and related substrates implicated in vascular control. In reproductive biology, LNPEP expression in placental tissue has positioned it as a candidate biomarker in preeclampsia research, where altered aminopeptidase activity correlates with impaired trophoblast invasion and maternal vascular dysfunction. Neuroscience applications include studies of cognitive function and memory consolidation, given the protein's documented role in hippocampal signaling pathways and its trafficking alongside GLUT4-containing vesicles.

Each kit provides 96 assays using a photometric readout compatible with standard microplate readers, supporting both small-scale pilot studies and larger cohort investigations. Sample handling should follow standard laboratory practice, with refrigerated storage recommended to preserve antigen integrity before processing. Reagents are supplied ready-to-use or in concentrated form depending on the specific component, with a complete protocol and plate layout included.

This kit is intended for research use only and serves laboratories exploring aminopeptidase biology, peptide hormone regulation, placental function, and related translational research areas.