Human LBR ELISA Kit (HUFI07722)

Developed by Assay Genie, this quantitative immunoassay enables researchers to measure endogenous levels of Lamin B Receptor (LBR), an integral inner nuclear membrane protein with dual roles in maintaining nuclear envelope architecture and catalyzing steps of cholesterol biosynthesis. The protein's involvement in chromatin tethering and heterochromatin anchoring at the nuclear periphery makes it a relevant biomarker for studies of membrane biology, chromatin organization, and inherited disorders such as Greenberg dysplasia and Pelger-Huët anomaly.

The assay is supplied as a complete microplate-based package containing pre-coated strip wells, lyophilized recombinant standards, biotinylated detection reagent, streptavidin-HRP conjugate, wash buffer, and TMB substrate, providing a full plate of determinations. All unopened components should be stored at 4 °C; reconstituted standards require freezing at -20 °C and aliquoting to limit freeze-thaw cycles, and the substrate must be protected from light. Intended for research use only and validated for in vitro laboratory workflows, the kit supports investigations into nuclear lamina dysfunction, hematological morphology, and sterol metabolism research.