Human LARS2 ELISA Kit (HUFI03651)

Mitochondrial protein translation relies on a dedicated set of aminoacyl-tRNA synthetases, including leucyl-tRNA synthetase 2 (LARS2), the product of the LARS2 gene. The Assay Genie Human LARS2 ELISA Kit is a quantitative in vitro immunoassay that measures this mitochondrial enzyme in human biofluid specimens, supporting research into disorders where LARS2 function is compromised, such as Perrault syndrome and non-syndromic sensorineural hearing loss.

Supplied as a complete 96 Assays package, the kit uses a paired-antibody capture format compatible with standard microplate readers and the included well plate. Sample types encompass serum or plasma collected from human subjects, enabling investigators to compare LARS2 levels across patient cohorts, matched controls, and time-course studies of mitochondrial disease progression. Each plate run generates a standard curve from the kit's calibrators, against which unknown sample readings are interpolated.

Applications include biomarker discovery for mitochondrial translation disorders, mechanistic studies of pathogenic LARS2 variants identified through genetic screening, and translational research into premature ovarian insufficiency and auditory dysfunction linked to LARS2 deficiency. The kit is intended for research use only and is suited to immunology, cell biology, and mitochondrial disease laboratories running targeted enzyme profiling on clinically annotated sample sets.