Human LAG3 PharmaGenie ELISA Kit (SBRS0818)

LAG3 (Lymphocyte Activation Gene-3, CD223) is a co-inhibitory immune checkpoint receptor expressed on activated CD4+ and CD8+ T lymphocytes, regulatory T cells, NK cells, and plasmacytoid dendritic cells. Binding MHC class II with higher affinity than CD4, LAG3 negatively regulates T cell proliferation, cytokine production, and effector function, positioning it as a central modulator of peripheral tolerance, chronic viral immunity, and tumor immune evasion.

This quantitative immunoassay kit from Assay Genie is supplied in a 96-assay format intended for research use only, supporting measurement of soluble human LAG3 in cell culture supernatant, plasma, and serum samples. The kit serves cancer immunotherapy studies investigating checkpoint blockade responses, autoimmune research examining Treg function, and infectious disease work tracking T cell exhaustion markers during chronic viral infection.

Each kit provides reagents for measuring LAG3 protein levels as a soluble biomarker of immune activation status, with batch processing capability for patient samples alongside reference standards to support longitudinal monitoring of checkpoint dynamics in clinical research cohorts.