Human Kynureninase PharmaGenie ELISA Kit (SBRS0816)

Kynureninase (KYNU) is a pyridoxal-5'-phosphate-dependent hydrolase that cleaves kynurenine and 3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, placing it at a pivotal branch point of the kynurenine pathway of tryptophan catabolism. Dysregulated KYNU expression has been linked to inflammatory signalling, immune tolerance, tumour immune escape, and central nervous system disorders in which altered kynurenine pathway flux is a recurring theme, driving demand for protein-level quantification in translational research workflows. This 96-assay kit from Assay Genie is configured for human reactivity and supports studies across multiple human sample matrices, pairing naturally with orthogonal readouts such as qPCR or western blot to map pathway activity in cell-based and biofluid-based investigations. Researchers commonly deploy such tools to monitor enzyme induction in cytokine-stimulated cultures, to survey donor cohorts in biomarker discovery, and to follow pathway-level changes in disease models.