Human KALRN ELISA Kit (HUFI03774)

Kalirin, the protein encoded by the KALRN gene, is a multi-domain Rho-family guanine nucleotide exchange factor that orchestrates cytoskeletal remodeling, dendritic spine formation, and synaptic plasticity. This Assay Genie microplate kit employs a human-specific capture antibody for quantitative measurement of native Kalirin, with no significant cross-reactivity observed against mouse or rat homologs under recommended conditions.

Typical research uses include schizophrenia and Alzheimer's biomarker discovery, coronary artery disease susceptibility studies tied to KALRN risk alleles, and mechanistic work on Rho GTPase signaling cascades. Reconstitute the lyophilized standard within 30 minutes of removal, store sealed components refrigerated between runs, and aliquot serum or plasma samples to limit freeze-thaw cycles beyond three. Researchers routinely load 100 uL per well, run the microplate in duplicate, and protect the streptavidin-HRP conjugate vial from light exposure during extended incubations.