Human Kallikrein 1 (KLK1) ELISA Kit

Dysregulation of the kinin-kallikrein system contributes to hypertensive and inflammatory disease states, and laboratories investigating these pathways rely on quantitative immunoassays to measure tissue kallikrein concentrations in clinical research samples. The Assay Genie Human Kallikrein 1 (KLK1) ELISA Kit provides a microplate-based platform for such measurements in human specimens, with KLK1 being a serine protease that cleaves kininogen to liberate bradykinin, a vasoactive peptide central to blood pressure regulation, vascular tone, electrolyte balance, and inflammatory signaling.

The assay targets native human KLK1 protein for quantification in laboratory settings and is intended for research use only. Standard workflow incorporates pre-coated wells, detection reagents, and a calibration standard series, enabling laboratories to construct a standard curve for KLK1 measurement across a working concentration range. The microplate-based colorimetric format supports biomarker investigations in human-derived samples for translational research in nephrology, hypertension, and vascular biology.

Researchers apply this kit to study tissue kallikrein involvement in conditions such as diabetic kidney disease, essential hypertension, and inflammatory disorders where altered bradykinin signaling has been documented. The kit is supplied with all reagents required to perform the run, packaged in vials, and includes a complete protocol covering sample preparation through result calculation in a single-use plate configuration.