Human INVS ELISA Kit (HUFI03802)

Built around the INVS gene product inversin, this Assay Genie ELISA Kit supports research on autosomal recessive nephronophthisis type 2, situs inversus, and broader ciliopathy biology. Mutations in INVS (also known as NPHP2) disrupt primary cilium function and non-canonical Wnt signaling, making quantitative measurement of the encoded protein relevant for kidney disease research, developmental biology studies, and investigations of planar cell polarity.

The kit provides 96 Assays and is configured for absorbance-based readout on standard microplate readers, intended for research use only. Its design accommodates studies of human biospecimens and cell line models, supporting comparisons of inversin abundance across patient samples, genotype groups, and experimental treatment conditions in cilia-focused laboratories.

Inversin localizes to the primary cilium and the embryonic node, where it acts in non-canonical Wnt signaling, patterning of left-right asymmetry, and maintenance of renal tubular epithelium. Investigators working on polycystic kidney disease mechanisms, Joubert syndrome overlap phenotypes, and congenital anomalies of laterality can apply the assay to track protein levels alongside functional readouts. Each pack ships with the reagents required for standard curve construction from a recombinant inversin calibrator and for quantification of endogenous protein in matched experimental and control samples.