Human Interleukin 21 Receptor (IL-21R) ELISA Kit

Quantify human interleukin-21 receptor levels with this colorimetric ELISA from Assay Genie. The kit targets IL-21R (CD360), a type I transmembrane cytokine receptor expressed across lymphoid lineages including T cells, B cells, NK cells, and dendritic cell populations. IL-21R partners with the common gamma chain (γc) to activate JAK1 and JAK3, triggering phosphorylation of STAT1, STAT3, and STAT5, and shaping downstream immune responses such as B-cell plasma cell differentiation, T follicular helper cell expansion, and NK cell maturation.

Researchers investigating systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and select B-cell malignancies including diffuse large B-cell lymphoma frequently monitor IL-21R expression as a biomarker of lymphocyte activation. The 96-assay configuration ships with a pre-coated microplate, lyophilized recombinant human IL-21R reference standard, biotinylated detection antibody, streptavidin-HRP conjugate, wash buffer, chromogenic substrate, and stop solution. The assay is validated for human reactivity and accepts tissue homogenates, cell lysates, and culture supernatants as input material for in vitro research use only. Store unused strips refrigerated and equilibrate all reagents to room temperature before running the protocol.