Human INPPL1 (Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2) ELISA KIT (HUFI08154)

The Assay Genie INPPL1 ELISA kit enables quantitative measurement of human phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, also known as SHIP2, in research samples. INPPL1 is a lipid phosphatase that hydrolyzes phosphatidylinositol (3,4,5)-trisphosphate at the 5-position, acting as a negative regulator of PI3K-mediated phosphoinositide signaling in the insulin receptor cascade.

Investigators apply this assay to examine INPPL1 expression in metabolic disease models, including insulin resistance, type 2 diabetes, and obesity-related dysfunction. The kit also supports oncology research, where SHIP2 has been implicated in cell proliferation, survival signaling, and cytoskeletal remodeling, as well as neuroscience work on synaptic plasticity and immune cell signaling studies.

Each kit ships with a pre-coated microplate, biotinylated detection antibody, standard diluents, and reagents sufficient for 96 determinations. Components should be refrigerated on arrival and protected from light; aliquoted standards tolerate limited freeze-thaw cycles. The kit is intended for research use only and is validated for human samples including cell lysates and tissue homogenates.