Human Inositol monophosphatase 1 (IMPA1) ELISA Kit

Manufactured by Assay Genie, this Sandwich ELISA kit is designed for the precise detection of Human Inositol monophosphatase 1 (IMPA1) levels in human serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. The kit specifically recognizes natural and recombinant human Inositol monophosphatase 1, with a detection range of 31.2-2000pg/mL and a sensitivity of 12pg/mL.

IMPA1 is a key enzyme in the phosphatidylinositol signaling pathway, regulating cell growth, differentiation, and survival. Dysregulation of IMPA1 has been associated with psychiatric disorders such as bipolar disorder and schizophrenia, making it a valuable biomarker for studying these conditions. The enzyme shows broad substrate specificity, acting on myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP. The protein forms a homodimer, is located in the cytoplasm, and is referenced under UniProt accession P29218.

Reported performance characteristics include an intra-assay CV of 4.2% and an inter-assay CV of 7.2%. Linearity ranges are 88-111% for serum, 89-118% for EDTA plasma, and 94-108% for heparin plasma across 1:2 to 1:16 dilutions. Recovery averages 87% (range 81-93%) for serum and 89% (range 83-95%) for plasma. For research use only.