Human HSCB ELISA Kit (HUFI03884)

The Assay Genie immunoassay quantifies human HSCB (HscB, approximately 26 kDa), a mitochondrial co-chaperone that operates within the iron-sulfur cluster (ISC) assembly machinery. HSCB partners with the mitochondrial Hsp70 chaperone (mtHsp70, encoded by HSPA9) to help deliver nascent iron-sulfur clusters to recipient apoproteins, supporting maturation of [2Fe-2S] and [4Fe-4S] proteins essential for electron transport chain function, mitochondrial DNA maintenance, and metabolic enzyme activity.

Researchers use quantitative HSCB measurement to investigate mitochondrial iron homeostasis, oxidative stress responses, and disorders linked to impaired cluster biogenesis, including ISCU myopathy and Friedreich's ataxia research. The kit is intended for research use only and supports in vitro study of mitochondrial chaperone function alongside cell culture and biochemical assays. Reagents are configured as a complete laboratory kit providing components sufficient for 96 Assays.

By enabling targeted detection of this co-chaperone, the product complements broader studies of mitochondrial protein homeostasis and iron metabolism, allowing researchers to monitor HSCB expression in patient-derived specimens and experimental models relevant to iron-sulfur cluster biology.