Human High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) ELISA Kit

A sandwich ELISA kit from Assay Genie designed for the quantitative detection of human High affinity immunoglobulin epsilon receptor subunit beta (MS4A2), also known as FcεRIβ. MS4A2 is described as a key receptor subunit involved in IgE-mediated immune responses and allergic reactions, and the manufacturer highlights its relevance as a biomarker for research into asthma, allergies, and autoimmune diseases.

The assay is intended for use with human samples, including serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids, with reactivity confirmed for human specimens. The manufacturer states that the kit shows specificity for natural and recombinant human High affinity immunoglobulin epsilon receptor subunit beta. The detection method is colorimetric, and the product is supplied for research use only.

According to the manufacturer, the kit offers a detection range of 78-5000pg/mL and a sensitivity of 41.3pg/mL. MS4A2 functions as a high-affinity receptor that binds the Fc region of immunoglobulin epsilon, and aggregation of the receptor by multivalent antigens is required for the full mast cell response, including degranulation and the de novo production of lipid mediators and cytokines. The protein is a multi-pass membrane component of a tetrameric receptor complex composed of an alpha chain, a beta chain, and two disulfide-linked gamma chains.