Human Heterogeneous nuclear ribonucleoprotein K (HNRNPK) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the quantitative detection of Human Heterogeneous nuclear ribonucleoprotein K (HNRNPK) in human samples. The assay detects natural and recombinant human HNRNPK and is for research use only.

Performance specifications include a detection range of 78-5000pg/mL and a sensitivity of 39pg/mL. Intra CV is 4.3% and Inter CV is 8.9%. Validated sample types include serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. Recovery averages 97% (range 91-103%) in serum and 99% (range 93-105%) in plasma. The target corresponds to Uniprot accession P61978, and the listed research area is Epigenetics.

HNRNPK is a multifunctional protein involved in RNA processing, gene transcription and DNA repair. It binds tenaciously to poly(C) sequences and contributes to p53/TP53-mediated responses to DNA damage at the level of both transcription activation and repression. Dysregulation of HNRNPK has been implicated in cancer, autoimmune disorders and neurological conditions, making the protein a relevant subject for studies of disease pathogenesis and potential therapeutic interventions.