Human Guanylate Cyclase Activator 2A (GUCA2A) ELISA Kit

Uroguanylin, the 16-amino acid peptide hormone encoded by GUCA2A, is secreted by intestinal enterochromaffin cells and binds the guanylyl cyclase 2C receptor to elevate intracellular cGMP, regulating intestinal fluid secretion, natriuresis, and epithelial ion transport. This quantitative immunoassay from Assay Genie measures endogenous uroguanylin in human research specimens using a 96-assay microplate format. It supports laboratory investigations of gut mucosal biology, salt and water homeostasis, and the reported reduction of GUCA2A expression in colorectal adenoma and carcinoma tissue contexts. The kit is configured for serum-derived, plasma-derived, and tissue homogenate samples in research use only, with all required standards and reagents supplied for quantifying peptide concentrations.