Human Gremlin 1 (GREM1) ELISA Kit

Gremlin 1 (GREM1) is a secreted BMP antagonist belonging to the DAN family of cystine-knot proteins, with established roles in embryonic development, tissue fibrosis, and tumor angiogenesis. This quantitative immunoassay from Assay Genie enables researchers to measure human GREM1 levels in research samples using an absorbance-based readout on a standard microplate reader.

The kit supplies 96 assays per box, supporting batch processing of unknowns alongside a standard curve for accurate interpolation. Documented research applications include studies of idiopathic pulmonary fibrosis, diabetic nephropathy, cancer invasion, and bone metabolism, where GREM1 modulates BMP signaling and is a candidate biomarker. The kit is configured for in vitro research use only and is shipped in a temperature-controlled pack to preserve reagent activity upon arrival.

Researchers evaluating BMP pathway involvement in chronic disease or development can pair this assay with complementary methods such as western blot, PCR, or immunohistochemistry to validate GREM1 expression changes in cell culture models and tissue-derived specimens.