Human GNB5  (Guanine nucleotide-binding protein subunit beta-5) ELISA Kit (HUFI04080)

This ELISA-format immunoassay from Assay Genie quantifies human GNB5, the beta-5 subunit of heterotrimeric G-proteins that relay signals from G-protein-coupled receptors across cell membranes. GNB5 pairs with G-alpha and gamma subunits to modulate downstream effectors including G-protein-regulated inward rectifier potassium channels, which are central to proper cardiac conduction and neuronal excitability. Loss-of-function variants in the GNB5 gene are linked to a neurodevelopmental syndrome featuring language delay, cognitive impairment, epilepsy, and sinus node dysfunction, making this kit a useful research tool for laboratories studying GPCR signalling pathways, neuronal signalling, and the molecular basis of GNB5-related disease.

The kit is supplied in a 96 Assays configuration for research use only, with components packaged in individual vials for reconstitution as directed in the supplied protocol. Investigators measuring circulating GNB5 should consult the package insert for the recommended dilution series, as the antigen is typically present at low abundance in biological samples.