Human Glial cell line-derived neurotrophic factor (GDNF) ELISA Kit

A high-quality sandwich ELISA kit from Assay Genie is designed for the quantitative measurement of human Glial cell line-derived neurotrophic factor (GDNF), also known by the synonyms Astrocyte-derived trophic factor (ATF) and hGDNF. The assay is for human reactivity and is validated for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, making it well suited to neuroscience research workflows.

Performance specifications include a detection range of 31.2-2000 pg/mL and a sensitivity of 14 pg/mL. Reported precision is an intra-assay CV of 6.3% and an inter-assay CV of 7.6%. Recovery is given as 92% on average (range 86-98%) for serum and 94% on average (range 88-100%) for plasma. Specificity is confirmed against natural and recombinant human GDNF.

GDNF is a secreted neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. The protein belongs to the TGF-beta family (GDNF subfamily) and exists as a disulfide-linked homodimer, referenced under UniProt P39905 with a molecular weight of 18,123 Da. The kit is intended for research use only.