Human Gasdermin-C (GSDMC) ELISA Kit

Designed for the precise quantitative measurement of Gasdermin-C in human samples, this ELISA kit from Assay Genie supports research into pyroptosis, a form of programmed cell death linked to inflammation and immune responses. Dysregulation of Gasdermin-C has been associated with cancer, autoimmune disorders, and infectious diseases.

The kit accepts serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids, with reactivity specific to human samples. Reported performance specifications include a detection range of 0.625–40 ng/mL, a sensitivity of 0.319 ng/mL, an intra-assay CV of 6.4%, and an inter-assay CV of 11.1%. Linearity has been validated in serum, EDTA plasma, and heparin plasma across dilutions from 1:2 to 1:16, and recovery averages 95% for serum and 97% for plasma.

Specificity covers natural and recombinant human Gasdermin-C (UniProt: Q9BYG8), also known as Melanoma-derived leucine zipper-containing extranuclear factor (MLZE). The target belongs to the gasdermin family, localises to the cytoplasm, cytosol, and cell membrane, and is of interest within cancer research. The product is supplied for research use only.