Human Gap Junction Protein Beta 1 (GJb1) ELISA Kit

Researchers investigating gap junction biology and connexin-mediated signaling can use the Assay Genie Human Gap Junction Protein Beta 1 (GJb1) ELISA Kit to quantitatively measure Connexin 32 protein levels in human tissue samples. Connexin 32, the transmembrane protein encoded by the GJB1 gene, assembles into gap junction channels that permit direct exchange of ions and small metabolites between adjacent cells. It is highly expressed in liver hepatocytes, Schwann cells of the peripheral nervous system, and renal tubular epithelium.

Loss-of-function mutations in GJB1 cause X-linked Charcot-Marie-Tooth disease type 1 (CMTX1), an inherited demyelinating neuropathy, which has motivated research into expression patterns of this connexin in patient-derived tissues and animal models. The kit accommodates studies of hepatic gap junction remodeling, peripheral nerve myelination, and auditory function, where Connexin 32 has been implicated in cochlear homeostasis.

Configured for 96 assays, the product is supplied as a complete reagent set for plate-based ELISA workflows using tissue homogenate preparations. A colorimetric readout enables standard laboratory spectrophotometric detection. Each kit is intended for research use only and supports reproducible quantification of human GJB1 protein in biological research applications, including investigations of gap junction communication in neural and hepatic systems.