Human Fucosidase Alpha L1, Tissue (FUCa1) ELISA Kit

Built for researchers investigating lysosomal storage disorders and glycoprotein catabolism, this quantitative immunoassay from Assay Genie measures alpha-L-fucosidase, the lysosomal hydrolase encoded by the FUCA1 gene, in human serum-derived specimens, plasma preparations, and homogenized tissue extracts. The kit supports studies of fucosidosis, a rare autosomal recessive condition where deficient enzyme activity drives progressive neurovisceral accumulation of fucose-containing glycoconjugates, and provides a reproducible tool for characterizing residual FUCA1 activity across patient-derived specimens and unaffected control cohorts.

Each kit contains reagents for 96 assays, performed in vitro under standard microplate immunoassay conditions and intended for research use only. The assay accommodates small sample volumes drawn from frozen or freshly prepared homogenized tissue, making it compatible with both clinical research workflows and basic investigations into glycosidase biology. The quantitative endpoint readout enables direct comparison of alpha-L-fucosidase levels between affected and unaffected individuals, monitoring of expression in disease models, and assessment of enzyme activity in transfected cell lines expressing wild-type or mutant FUCA1 constructs.

Researchers focused on biomarker discovery, rare disease characterization, or lysosomal enzyme replacement strategies can integrate this ELISA platform into standard laboratory workflows that include sample preparation, sequential incubation steps, and absorbance measurement for endpoint quantification.