Human Frizzled-8 (FZD8) ELISA Kit

A sandwich ELISA from Assay Genie designed for the accurate measurement of Frizzled-8 (FZD8) levels in human samples. The assay provides reliable and reproducible results for researchers studying the role of FZD8 in various biological processes.

FZD8 is a member of the Frizzled family of proteins involved in the Wnt signaling pathway, playing a critical role in cell proliferation, differentiation, and development. Dysregulation has been implicated in cancer, neurological disorders, and developmental abnormalities. By accurately measuring FZD8 levels, researchers can gain valuable insights into disease progression and potential therapeutic targets.

The kit uses a colorimetric detection method and is reactive with human samples. Validated sample types include serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with specificity for natural and recombinant human Frizzled-8. The detection range is 31.2-2000pg/mL with a sensitivity of 15.6pg/mL. The UniProt accession is Q9H461. FZD8 functions as a receptor for Wnt proteins and is a component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling, leading to activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. The kit is also known by the synonym Fz-8 and is for research use only.