Human Forkhead box protein O3 (FOXO3) ELISA Kit

Designed for the precise measurement of human Forkhead box protein O3, this Sandwich ELISA Kit from Assay Genie supports research into apoptosis, oxidative stress response, and longevity. FOXO3, a member of the forkhead box protein O subfamily, has been linked to cancer, diabetes, and aging-related disorders, making it a valuable target for biomedical investigation.

The kit has a detection range of 0.312-20 ng/mL and a sensitivity of 0.1 ng/mL, and is intended for use with human serum and plasma samples. Performance characteristics include an intra-assay CV of 4.1% and an inter-assay CV of 8.2%. Linearity data spans dilutions from 1:2 to 1:16 across serum, EDTA plasma, and heparin plasma matrices. Recovery in serum averages 95% (range 89-101%) and in plasma averages 97% (range 91-103%).

FOXO3 functions as a transcriptional activator that triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognises and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and participates in post-transcriptional regulation of MYC. For research use only.