Human Flt-3/Flk-2 PharmaGenie ELISA Kit (SBRS0589)

Flt-3/Flk-2 (also known as CD135) is a class III receptor tyrosine kinase expressed on hematopoietic progenitor cells, where it regulates proliferation, differentiation, and survival through binding to its ligand FLT3L. Dysregulated signaling, often involving internal tandem duplications or tyrosine kinase domain point mutations, is a frequent driver of acute myeloid leukemia, making Flt-3 an important biomarker in hematological and oncology research.

This Assay Genie ELISA Kit quantifies soluble human Flt-3/Flk-2 protein in cell culture supernatant and in human plasma or serum specimens using a colorimetric readout. The 96-assay format supports mid-throughput studies of cytokine signaling, leukemia cell biology, and hematopoietic stem cell characterization. Investigators studying immune reconstitution, minimal residual disease, or therapeutic response monitoring can apply the kit to examine Flt-3 ligand pathway activity across normal progenitor populations and malignant myeloid cell lines.