Human FDPS ELISA Kit (HUFI04295)

Quantification of human Farnesyl Diphosphate Synthase (FDPS) supports research into bone metabolism, lipid biosynthesis, and oncology. The enzyme catalyzes sequential head-to-tail condensations of isopentenyl diphosphate and dimethylallyl diphosphate within the mevalonate pathway, generating the prenyl precursors required for cholesterol synthesis, protein prenylation, and dolichol production. By providing a dedicated immunoassay for FDPS protein levels, the Assay Genie kit enables researchers to track pathway activity in human-derived specimens and correlate enzyme abundance with disease state or pharmacological response.

FDPS is the molecular target of nitrogen-containing bisphosphonates such as zoledronate and alendronate, making this kit valuable for studies of osteoporosis, bone metastasis, and Paget's disease. Elevated FDPS expression has been documented in breast, prostate, and lung tumor tissue, linking the enzyme to cancer cell proliferation and statin-sensitivity research. Applications extend to investigations of mevalonate pathway dysregulation, hypercholesterolemia, and prenylation-dependent signaling cascades involving Ras and Rho GTPases.

The Assay Genie FDPS ELISA is intended for in vitro research use only and is supplied in a single-use microplate format. Researchers measuring FDPS in cell lysates, tissue homogenates, or clinical specimens can integrate the kit into existing immunoassay workflows to support biomarker discovery and mechanistic studies of prenyl lipid metabolism.