Human FBXW7 ELISA Kit (HUFI04311)

The FBXW7 protein (F-box and WD repeat domain containing 7, also called FBW7 or hCDC4) is a substrate recognition component of the SCF E3 ubiquitin ligase complex and acts as a key tumor suppressor across many cancer types. Mutations in FBXW7 are among the most frequent genetic alterations in colorectal, gastric, endometrial, and cholangiocarcinomas, where loss of function leads to stabilization of oncoproteins such as c-Myc, cyclin E, Notch, and c-Jun. This Assay Genie kit enables quantitative measurement of human FBXW7 in serum and plasma samples for oncology and cell biology research, with no significant cross-reactivity reported with mouse or rat homologues.

Absorbance is read on a standard microplate reader, and all reagents are supplied for research use only in vitro workflows. Unopened kits are typically refrigerated, while reconstituted standards and detection antibody should be aliquoted and frozen to limit freeze-thaw cycles and preserve immunoreactivity across the full 96 Assays run.