Human FBXO32 (F-box only protein 32) ELISA Kit (HUFI04730)

FBXO32, also known as MAFbx or Atrogin-1, is a muscle-specific F-box protein and established biomarker of skeletal muscle atrophy. This Assay Genie ELISA Kit provides researchers with a quantitative tool to measure FBXO32 protein levels, supporting investigations into cachexia, sarcopenia, disuse muscle wasting, and metabolic disorders affecting muscle mass.

As a component of the ubiquitin-proteasome degradation pathway, FBXO32 is transcriptionally upregulated during accelerated muscle protein breakdown. Its expression rises in conditions such as cancer cachexia, prolonged immobilization, chronic kidney disease, glucocorticoid treatment, and denervation atrophy, making the protein valuable for tracking muscle catabolism in clinical and translational research settings.

Applications of this quantitative ELISA kit from Assay Genie include studies of exercise physiology, rehabilitation interventions, age-related muscle loss, nutritional supplementation research, and pharmaceutical screening for anti-atrophy compounds. Researchers can apply the kit format to investigate molecular mechanisms underlying muscle homeostasis and to evaluate therapeutic strategies aimed at preserving lean tissue mass in patient populations experiencing involuntary muscle wasting.