Human EXOSC8 ELISA Kit (HUFI07932)

The EXOSC8 protein, also known as Exosome Component 8 or RRP43, is a catalytic subunit of the multi-subunit RNA exosome complex responsible for 3'-to-5' RNA degradation and processing in eukaryotic cells. This Assay Genie immunoassay enables quantitative measurement of EXOSC8 in human research samples, supporting studies of RNA turnover, ribosome biogenesis, and neurodegenerative disease pathways. Mutations in EXOSC8 have been linked to pontocerebellar hypoplasia type 1C, a severe autosomal recessive disorder characterized by underdevelopment of the cerebellum and brainstem, making accurate protein quantification valuable for mechanistic and translational neuroscience research. The kit is supplied as a complete package with all reagents necessary for the immunoassay workflow, including pre-coated microplate wells, detection antibodies, and substrate solution. For optimal stability, components should be stored at -20 °C upon receipt, with repeated freeze-thaw cycles avoided by aliquoting working solutions. Researchers commonly use this reagent to investigate EXOSC8 expression profiles in patient-derived specimens or model systems, aiming to elucidate the molecular basis of exosome-mediated RNA surveillance.