Human Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 1 (ERCC1) ELISA Kit

Quantitative measurement of the Excision Repair Cross-Complementing 1 (ERCC1) protein supports research into nucleotide excision repair, a major DNA damage response pathway in which ERCC1 dimerizes with XPF (ERCC4) to excise bulky helix-distorting DNA lesions. Assay Genie supplies this human-reactive ELISA Kit in a 96 assays configuration for studies involving tissue homogenates and cell lysates prepared from cell culture models or clinical biopsy material.

ERCC1 expression is a frequently studied predictive biomarker in translational oncology, most prominently in non-small cell lung cancer where reduced ERCC1 levels have been associated with greater sensitivity to platinum-based chemotherapy such as cisplatin and carboplatin. Researchers also use ERCC1 quantification to investigate chemoresistance mechanisms, DNA repair capacity, and drug development programs targeting repair-deficient tumors.

The kit is intended for research use only and supports applications including biomarker screening, validation of patient-derived samples, and in vitro pharmacology studies. Each kit contains the reagents needed to perform the assay under standard laboratory conditions.