Human Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) ELISA Kit

Quantitative measurement of human EIF4A2 protein levels supports translational research into RNA helicase biology and related disease pathways. Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) is a DEAD-box RNA helicase best characterized for its role in microRNA-mediated gene silencing, where it is recruited to target messenger RNAs and engages the CCR4-NOT deadenylase complex to repress translation. EIF4A2 also contributes to stress granule assembly under cellular stress and, in defined contexts, participates in cap-dependent translation initiation as a paralog of the more abundant EIF4A1.

The Assay Genie kit delivers a colorimetric readout configured for 96 determinations, supplied as a complete pack of 96 assays, and validated for use with human samples including tissue homogenates. Researchers apply this kit to studies of translation factor dysregulation in oncology, where altered EIF4A2 expression has been documented in hepatocellular carcinoma and cervical cancer, as well as investigations into neurodevelopmental disorders linked to EIF4A2 variants. The assay supports quantification across in vitro cell lysate preparations and ex vivo tissue specimens, making it a practical tool for laboratories comparing EIF4A2 levels across disease models versus matched controls.