Human esRAGE (Endogenous secretory Receptor for Advanced Glycation End product) ELISA Kit (HUFI04782)

Quantify endogenous secretory RAGE (esRAGE), a soluble splice variant of the Receptor for Advanced Glycation End products, with this ELISA kit from Assay Genie. The esRAGE isoform lacks the transmembrane domain of full-length RAGE and is secreted into circulation, where it acts as a decoy receptor that sequesters Advanced Glycation End products and modulates downstream inflammatory signaling cascades.

Because of this biology, circulating esRAGE concentrations are studied as a candidate biomarker in type 2 diabetes, insulin resistance, atherosclerosis, cardiovascular disease, chronic kidney disease, and aging-related research. The assay supports quantitative measurement in human research specimens and enables cross-sectional studies, longitudinal cohort monitoring, and case-control comparisons. Researchers typically pair esRAGE readouts with complementary markers such as total sRAGE, AGE-modified proteins, HbA1c, or inflammatory cytokines to map RAGE-axis activity.

The 96 Assays configuration delivers mid-throughput capacity for clinical and experimental sample sets. The workflow follows a standard ELISA procedure with absorbance-based readout, and the kit is intended for research use only in appropriately equipped laboratories.