Human EIF2B4 ELISA Kit (HUFI04473)

The EIF2B4 gene encodes the delta subunit of eukaryotic translation initiation factor 2B, a guanine nucleotide exchange factor required for protein synthesis initiation. Loss-of-function mutations in this gene cause leukoencephalopathy with vanishing white matter, a rare autosomal recessive neurological disorder characterized by progressive demyelination and triggered by physiological stressors such as fever or head trauma.

This colorimetric ELISA kit from Assay Genie enables quantitative detection of human EIF2B4 protein in research specimens. The 96 Assays configuration provides ample throughput for cohort comparisons and time-course studies of translational control. The assay uses a standard microplate reader setup and is validated for research use only, supporting investigations into translation regulation, the integrated stress response, guanine nucleotide exchange activity, and eIF2B-related leukodystrophies.

Researchers examining eIF2B complex assembly, ER stress signaling, ribosome recycling, or the molecular basis of vanishing white matter disease can apply this kit to evaluate protein abundance across experimental conditions, patient-derived samples, and cell culture models.