Human DNM1L  (Dynamin-1-like protein) ELISA Kit (HUFI05290)

The Assay Genie Human DNM1L (Dynamin-1-like protein) ELISA Kit enables quantitative measurement of Drp1, the cytosolic GTPase responsible for mitochondrial outer membrane fission, in human research samples. Investigators in mitochondrial biology use this immunoassay to profile Drp1 levels in studies of metabolic disease, neurodegeneration, and programmed cell death pathways.

Each well plate run requires a 100 µL sample aliquot, with recombinant human Drp1 calibrators providing the standard curve for accurate interpolation. The capture and detection antibody pair is human-specific, with no significant cross-reactivity against related dynamin family members such as DNM1 or DNM2, allowing selective Drp1 quantification in mixed lysate or circulating specimen preparations.

Research applications span investigations of mitochondrial fragmentation in Parkinson's and Alzheimer's disease models, cardiac ischemia-reperfusion injury studies, and oncology work examining Drp1-dependent tumor cell survival mechanisms. The sealed components should be kept refrigerated until first use, with reconstituted reagents stored according to the protocol insert.