Human DGUOK (Deoxyguanosine kinase, mitochondrial) ELISA KIT (HUFI05298)

Mitochondrial deoxyguanosine kinase (DGUOK) catalyzes the phosphorylation of deoxyguanosine and deoxyadenosine within the purine salvage pathway, providing precursors essential for mitochondrial DNA synthesis. Mutations in DGUOK cause the hepatocerebral form of mitochondrial DNA depletion syndrome, an autosomal recessive disorder, so quantitative measurement of the enzyme supports research into mtDNA maintenance disorders, nucleoside metabolism, and candidate therapies. The kit from Assay Genie is configured for in vitro research use only and contains the reagents required for a quantitative ELISA workflow. Researchers apply it to studies of mitochondrial biogenesis, investigation of dNTP pool imbalances, and characterization of cell or tissue lysates in hepatic and neurological disease models.