Human Desmoglein 2 (DSG2) ELISA Kit

Quantitative measurement of Desmoglein 2 in human specimens is supported by this immunoassay kit from Assay Genie, designed to detect the desmosomal cadherin DSG2 that anchors adjacent cardiomyocytes within cardiac intercalated discs and links epithelial sheets in simple and stratified tissues. Because DSG2 mutations are causal in a subset of familial arrhythmogenic right ventricular cardiomyopathy, the kit serves investigators working on inherited arrhythmia syndromes, sudden cardiac death etiology, and the molecular remodeling that follows myocardial injury.

Beyond cardiac applications, researchers use DSG2 quantification to study epithelial barrier integrity in dermatology, to monitor circulating cadherin fragments as candidate biomarkers of tissue stress, and to examine how altered desmosomal adhesion contributes to tumor cell invasion and epithelial-mesenchymal transition in carcinoma models. The kit is validated for human sample types including serum-derived, plasma-derived, and tissue homogenate preparations, supporting both systemic readouts and tissue-level analyses. Each kit ships with pre-coated microplate wells and is intended for research use only, not for clinical diagnostic decisions.

For optimal reagent stability, components should be refrigerated and protected from light until first use, and freeze-thaw cycles of prepared reagents minimized. The assay integrates with standard plate readers, allowing laboratories to run DSG2 alongside other ELISA-format analytes in cardiovascular or oncology biomarker panels. Researchers new to desmosomal protein quantification should consult the enclosed protocol for calibration curve preparation and recommended dilution ranges for each specimen type.