Human Desmocollin 2 (DSC2) ELISA Kit

Quantitative measurement of human Desmocollin 2 (DSC2) protein in research samples is supported by this ELISA Kit from Assay Genie. DSC2 is a calcium-dependent transmembrane glycoprotein of the cadherin family that forms the adhesive core of desmosomes, intercellular junctions that couple intermediate filaments to the plasma membrane and provide mechanical resilience to tissues subjected to repeated shear stress.

This kit serves multiple research programs. In cardiovascular biology, DSC2 sits alongside PKP2, DSP, DSG2, and JUP as one of the desmosomal genes linked to arrhythmogenic right ventricular cardiomyopathy (ARVC), so quantifying protein abundance complements genetic and histological workup of patient variants. In epithelial biology and oncology, reduced DSC2 expression has been documented in squamous cell carcinomas and other tumors where weakened desmosomal adhesion contributes to invasion and metastasis. The kit is also relevant to dermatology research, since DSC2 is highly expressed in the stratified squamous epithelium of the skin.

Each kit is supplied as a complete package with pre-coated plate wells, calibrators, detection antibodies, and assay buffer. Store reagents refrigerated upon receipt, keep them protected from light, and allow equilibration to room temperature before running the protocol. The product is designated for research use only in in vitro laboratory settings.