Human Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (CDKN2A) ELISA Kit

Assay Genie provides this Sandwich ELISA Kit using a colorimetric detection method for the quantitative detection of human Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (CDKN2A) in research applications. The kit is designed for use with human serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids, and shows specificity for natural and recombinant human CDKN2A.

CDKN2A acts as a negative regulator of normal cell proliferation by interacting strongly with CDK4 and CDK6, inhibiting their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The protein is located in the cytoplasm and nucleus. Abnormalities in CDKN2A expression have been linked to various cancers, making it a valuable biomarker for studying disease pathogenesis.

Key assay specifications include a detection range of 1.56-100 ng/mL and a sensitivity of 0.98 ng/mL. The kit is intended for research use only, and components should be stored at -20°C.