Human Cyclin-dependent kinase 4 inhibitor C (CDKN2C) ELISA Kit

Assay Genie offers a colorimetric Sandwich ELISA for the quantitative detection of human Cyclin-dependent kinase 4 inhibitor C (CDKN2C). The assay detects natural and recombinant human CDKN2C in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and is intended for research use only, with applications in cancer research.

Manufacturer-reported performance includes a detection range of 0.156-10ng/mL, a sensitivity of 0.1ng/mL, an intra-assay CV of 6.5% and an inter-assay CV of 9.8%. Linearity in serum, EDTA plasma and heparin plasma at dilution factors from 1:2 to 1:16 spans 83-117%. Recovery in serum averages 106% (range 100-112%) and in plasma averages 108% (range 102-114%).

CDKN2C is described as a member of the INK4 family of cyclin-dependent kinase inhibitors that interacts strongly with CDK6 and weakly with CDK4, functioning as a cell growth regulator that controls cell cycle G1 progression. The protein has a reported molecular weight of 18kDa (UniProt P42773). Synonyms listed by the manufacturer include Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6 and CDKN6.