Human Cross-linked C-terminal telopeptide of Collagen alpha-1 (I)chain (ICTP) ELISA Kit

Developed by Assay Genie, this ELISA Kit is designed for the accurate detection of Cross-linked C-terminal telopeptide of Collagen alpha-1(I) chain (ICTP) in human samples. ICTP is a key biomarker for bone turnover, reflecting the breakdown of type I collagen in the bone matrix. Elevated levels of ICTP are associated with conditions such as osteoporosis, Paget's disease, and bone metastases, making this kit a valuable tool for researchers studying bone metabolism, collagen degradation, and various bone-related disorders.

The assay is validated for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with reactivity specific to human samples. It offers a detection range of 0.156-10ng/mL and a sensitivity of 0.044ng/mL. Precision is supported by an intra-assay CV of 4.4% and an inter-assay CV of 8.1%. Linearity has been demonstrated in serum, EDTA plasma, and heparin plasma across dilutions of 1:2, 1:4, 1:8 and 1:16. Recovery in serum is 98% (range 92-104%) and in plasma is 100% (range 94-106%).

The kit is specific for natural and recombinant human Cross-linked C-terminal telopeptide of Collagen alpha-1(I) chain and is intended for research use only. It provides reliable and reproducible results with precise quantification capabilities, making it an invaluable tool for monitoring disease progression and assessing treatment efficacy.