Human CRK (Adapter molecule crk) ELISA KIT (HUFI04802)

CRK is an SH2/SH3-domain adapter molecule originally identified as the cellular homolog of the v-crk oncogene carried by the CT10 avian sarcoma virus. It bridges phosphotyrosine signaling to downstream effectors that govern cytoskeletal remodeling, cell adhesion, and migration, and is expressed as two main isoforms, CRK-I and CRK-II, with CRK-II carrying an additional regulatory linker region subject to Abl-mediated phosphorylation. This quantitative immunoassay from Assay Genie is configured for measurement of human CRK in research samples using a colorimetric readout. It serves investigators studying focal adhesion dynamics, p130Cas and paxillin scaffolding complexes, receptor tyrosine kinase crosstalk, and tumor cell motility pathways, and is supplied as 96 Assays for research use only within signaling networks relevant to cancer progression, chronic myeloid leukemia research, and developmental cell migration studies.