Human CREB Binding Protein (CREBBP) ELISA Kit

Assay Genie provides a quantitative ELISA platform for measuring CREB Binding Protein abundance in human research samples. The CREBBP protein acts as a transcriptional coactivator with intrinsic histone acetyltransferase activity, regulating chromatin structure through lysine acetylation on histones H3 and H4 while interacting with transcription factors including CREB, p53, MYB, and multiple nuclear receptors.

The kit runs 96 assays per box and accepts tissue homogenates as the primary sample input, supporting studies of protein abundance across experimental conditions. CREBBP contains a bromodomain that reads acetylated lysine marks, linking histone modification status to downstream transcriptional programs in normal and disease contexts.

Loss-of-function mutations in the CREBBP gene cause Rubinstein-Taybi syndrome, and somatic alterations appear across diffuse large B-cell lymphoma and acute lymphoblastic leukemia, making the protein a target of interest in oncology, developmental biology, and chromatin research.