Human Collagen Type I Alpha 1 (COL1a1) ELISA Kit

Type I collagen, the most abundant fibrillar collagen in the human body, forms the structural backbone of bone, dermis, tendon, ligament, cornea, and dentin. Quantifying COL1a1 protein levels in human samples supports research into fibrosis, osteogenesis imperfecta, and connective tissue disorders, where altered collagen deposition is a hallmark of hepatic, pulmonary, and renal scarring as well as tumor-stroma interactions.

The Assay Genie Human Collagen Type I Alpha 1 (COL1a1) ELISA Kit is configured for 96 assays and uses a colorimetric readout compatible with standard microplate ELISA workflows. The kit is intended for research use only and should be refrigerated to preserve reagent stability. Reconstituted standards should be aliquoted to minimize freeze-thaw cycles, supporting reproducible measurements across experimental runs.

Applications include measuring collagen turnover in cell culture supernatants, profiling fibrogenic signaling in tissue homogenates, and monitoring extracellular matrix remodeling in translational studies. Investigators studying wound healing, bone formation, scleroderma, and extracellular matrix biology use COL1a1 quantification as a marker of matrix production and disease progression.