Human Cardiac phospholamban (PLN) ELISA Kit

Assay Genie provides a Sandwich ELISA Kit for the accurate quantification of phospholamban levels in human cardiac tissue samples. The kit offers high sensitivity and specificity, delivering reliable and reproducible results across a range of cardiovascular research applications, and is supplied for research use only.

Performance specifications include a detection range of 0.312-20ng/mL and a sensitivity of 0.1ng/mL. Precision is reported as an intra-assay CV of 6.5% and an inter-assay CV of 9.1%. Linearity has been validated for serum, EDTA plasma, and heparin plasma across multiple sample dilutions, and recovery has been confirmed in serum and plasma matrices. The assay is specific for natural and recombinant human Cardiac phospholamban (synonyms: PLB) and is compatible with serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids.

Phospholamban is a critical regulatory protein in heart muscle that reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum, modulating cardiac contractility and calcium re-uptake during muscle relaxation. Dysregulation of phospholamban has been implicated in heart failure and arrhythmias, making it a valuable biomarker for studying these conditions. The corresponding UniProt accession is P26678.