Human Carboxylesterase 2/CES2 PharmaGenie ELISA Kit (SBRS0411)

Quantitative measurement of human Carboxylesterase 2 (CES2) protein is supported by this PharmaGenie ELISA Kit from Assay Genie, developed for researchers studying drug metabolism, pharmacokinetics, and hepatic or intestinal biochemistry. CES2 is a serine hydrolase enriched in the liver and small intestine, where it contributes to prodrug activation and the hydrolysis of ester-containing pharmaceuticals such as irinotecan.

Configured for 96 assays, the kit is validated with cell culture supernatants, plasma, and serum samples of human origin. Typical applications include profiling CES2 expression in hepatic cell models, characterizing metabolic enzyme capacity in donor-derived specimens, and screening compounds for CES2-mediated hydrolysis in vitro during early-stage drug discovery.

Reagents are supplied in a microplate format with capture-antibody pre-coating, detection antibody, enzyme conjugate, calibrator standards, wash buffer, and substrate. The colorimetric readout is compatible with standard plate readers. Storage should be refrigerated upon arrival to preserve component activity, and all materials are intended for research use only.