Human C-X-C chemokine receptor type 4 (CXCR4) ELISA Kit

Assay Genie provides a Sandwich ELISA Kit for the quantitative detection of human C-X-C chemokine receptor type 4 (CXCR4) in research applications. The kit is intended for use with human samples and has been validated for serum, plasma, tissue homogenates, cell culture supernates and other biological fluids.

Performance figures include a detection range of 0.156-10ng/mL and a sensitivity of 0.052ng/mL. Intra-assay CV is reported at 7.8% and inter-assay CV at 11.2%. The assay recognises natural and recombinant human C-X-C chemokine receptor type 4 (UniProt P61073) and is listed under the Neuroscience research area. For research use only.

Linearity has been evaluated across 1:2 to 1:16 dilutions in serum (105-114% to 94-104%), EDTA plasma (84-94% to 80-90%) and heparin plasma (85-94% to 117-127%). Recovery is reported as 102% for serum (range 96-108%) and 104% for plasma (range 98-110%). CXCR4 is a chemokine receptor involved in immune responses, cell migration and tumour metastasis, and its dysregulation has been implicated in cancer, HIV/AIDS and inflammatory disorders, making its measurement relevant to studies of disease progression and potential treatment strategies.