Human Breast cancer type 2 susceptibility protein (BRCA2) ELISA Kit

A sandwich ELISA from Assay Genie for the quantitative measurement of human Breast Cancer Type 2 Susceptibility Protein (BRCA2) in research samples. The assay is reactive with human serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids and is intended for research use only.

BRCA2 is a tumour-suppressor protein that functions in DNA double-strand break repair and homologous recombination, and mutations in the BRCA2 gene are linked to an increased risk of hereditary breast and ovarian cancer. The kit therefore supports studies exploring DNA repair biology, cancer susceptibility and biomarker discovery within the cancer research field.

Performance characteristics include a detection range of 0.156–10 ng/mL and a sensitivity of 0.078 ng/mL, with reported intra-assay CV of 6.2% and inter-assay CV of 10.9%. Alternative names for the target include Fanconi anemia group D1 protein, FACD and FANCD1. The protein is described as localising to the nucleus, cytoplasm, cytoskeleton, microtubule-organising centre and centrosome.