Human Bone Sialoprotein (BSP) ELISA Kit

Bone Sialoprotein, encoded by the IBSP gene, is a phosphorylated glycoprotein that constitutes a major non-collagenous component of the bone extracellular matrix. Researchers studying bone metabolism, osteoblast differentiation, and skeletal mineralization rely on quantitative measurement of this marker to track osteogenic activity and matrix deposition. Beyond skeletal biology, circulating Bone Sialoprotein levels are investigated as a biomarker in metastatic bone disease, particularly in breast and prostate cancer patients, where elevated BSP has been associated with tumor progression and bone lesion burden.

This quantitative immunoassay from Assay Genie is configured for human-origin specimens and accepts blood plasma fractions, serum fractions, tissue homogenates, and cell culture supernatants. Each kit provides reagents for 96 determinations in a microplate strip format with a spectrophotometric readout suitable for standard laboratory plate readers. The assay supports research into periodontal disease, dental implant integration, and conditions involving altered bone turnover such as osteoporosis and Paget's disease. Researchers studying the RGD-containing cell adhesion domain of BSP, or its binding to hydroxyapatite, will find this a useful tool for measuring protein concentration in experimental samples.