Human Azurocidin/CAP37/HBP PharmaGenie ELISA Kit (SBRS0288)

The assay quantifies azurocidin, a 37 kDa serine-protease homolog stored in neutrophil azurophilic granules and released during degranulation. Also referred to as CAP37 (cationic antimicrobial protein) and HBP (heparin-binding protein), the molecule drives monocyte chemotaxis, enhances vascular permeability, and exerts direct antimicrobial activity against bacterial and fungal pathogens. Assay Genie supplies this kit to support research into neutrophil-driven inflammation, sepsis biomarkers, and innate immune signaling.

Clinical investigators have measured circulating HBP/azurocidin concentrations as an early indicator of severe sepsis and septic shock, frequently rising before conventional clinical deterioration markers. The same analyte has been investigated in acute respiratory distress syndrome, severe burn injury, and bacterial meningitis, where neutrophil activation is a central pathogenic feature.

For laboratory use, the kit accepts cell culture supernatant, plasma, and serum samples. A colorimetric endpoint is read on a standard microplate reader. Reagents are supplied in a kit format sized for 96 determinations per plate, with a pre-coated plate and matched detection antibody included. Research use only; store refrigerated and protect light-sensitive components from exposure until first use.