Human ATP Binding Cassette Transporter G2 (ABCG2) ELISA Kit

This targeted ELISA Kit from Assay Genie enables quantitative measurement of human ATP Binding Cassette Transporter G2 (ABCG2) in tissue homogenates and cell lysates. ABCG2, also known as Breast Cancer Resistance Protein (BCRP), is a half-transporter of the G subfamily of ATP-binding cassette transporters and mediates cellular efflux of xenobiotics, chemotherapeutics, and endogenous substrates. Researchers in oncology and pharmacology rely on ABCG2 as a biomarker of multidrug resistance, since its overexpression in tumor cells contributes to the efflux of agents such as mitoxantrone and topotecan. The kit also supports studies of barrier-tissue transport at the placenta, blood-brain barrier, kidney, and intestine, where ABCG2 governs drug disposition and protective substrate handling. Application areas include inhibitor screening, characterization of transporter polymorphisms, and pharmacokinetic profiling in cancer cell models. Absorbance-based readout is captured on a standard microplate reader, with the assay configured as a 96-assay kit for research use only. Validated sample types include tissue homogenates, cell lysates, and related sample preparations. For laboratories investigating efflux-pump biology, drug-resistance mechanisms, or transporter-mediated pharmacokinetics, this targeted immunoassay offers a focused solution from Assay Genie.